Degrees and Appointments
- B.S. Chemistry, 1989, Northern Arizona University
- Ph.D. Chemistry, 1996, University of California, Santa Barbara
- Postdoctoral Fellow, 1996-1998, Department of Cell Biology and Physiology, University of New Mexico School of Medicine
- Cancer Research Fellow, 1998-2002, National Cancer Institute, NIH
Awards and Honors
- NSF CAREER Award, 2007
- Presidential Early Career Award for Scientists and Engineers (PECASE), 2008
- Achievement Award for Outstanding Mentor of Graduate/Professional Students (GPS), GPS Council, 2010
- Fellow of the American Association for the Advancement of Science (AAAS), 2013
- College of Science Distinguished Advising Award, University of Arizona, 2014
D.D. Thomas, J.L. Heinecke, L.A. Ridnour, R. Cheng, A.H. Kesarwala, C.H. Switzer, D.D. Roberts, S. Glynn, J.M. Fukuto, D.A. Wink*, K.M. Miranda*, "Nitrosative Signaling and Stress: the Redox Landscape in NOS2 biology", Free Radic. Biol. Med., 87, 204-225 (2015).
D. Basudhar, R.C. Cheng, G. Bharadwaj, L.A. Ridnour, D.A. Wink, K.M. Miranda*, "Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer", Free Radic. Biol. Med., 83, 101-114 (2015).
J.H. Jorolan, L.A. Buttitta, C. Cheah, K.M. Miranda*, "Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion", Nitric Oxide, 44, 39-46 (2015).
R.Y.S. Cheng, D. Basudhar, L.A. Ridnour, J. Heinecke, A.H. Kesarwala, S. Glynn, C.H. Switzer, S. Ambs, K.M. Miranda, D.A. Wink*, "Gene expression profiles of NO- and HNO-donor treated breast cancer cells: Insights into tumor response and resistance pathways", Nitric Oxide, 43, 17-28 (2014).
G.M. Johnson, T.J. Chozinski, E.S. Gallagher, C.A. Aspinwall, K.M. Miranda*, "Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl following exposure to therapeutic levels of donors", Free Radic. Biol. Med., 76, 299-307 (2014).
L. Staurengo-Ferrari, A.C. Zarpelon, D.T. Longhi-Balbinot, M. Marchesi, T.M. Cunha, J.C. Alves-Filho, F.Q. Cunha, S.H. Ferreira, R. Casagrande, K.M. Miranda, W.A. Verri, Jr*, "Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway", Pharmacol. Rep., 66, 691-698 (2014).
D. Basudhar, G. Bharadwaj, R.Y. Cheng, S. Jain, S. Shi, L.A. Ridnour, V.M. Caceres, R.C. Spadari-Bratfisch, N. Paolocci, C.A. Velázquez-Martínez, D.A. Wink, K.M. Miranda*, "Synthesis and comparison of nitroxyl and nitric oxide releasing diazeniumdiolate-based aspirin derivatives", J. Med. Chem., 56, 7804-7820 (2013).
T. Heinrich, R. da Silva, K.M. Miranda, C.H. Switzer, D.A. Wink, J.M. Fukuto*, "Biological nitric oxide signaling: chemistry and terminology", Br. J. Pharmacol., 169, 1417-1429 (2013).
G.M. Johnson, T.J. Chozinski, D.J. Salmon, A.D. Moghaddam, H.C. Chen. K.M. Miranda*, "Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent", Free Radic. Biol. Med., 63, 476-484 (2013).
Corrigendum, Free Radic. Biol. Med., 77, 390 (2014).
D.J. Salmon, C.L. Torres de Holding, L. Thomas, K.V. Peterson, G.P. Goodman, J.E. Saavedra, A.Srinivansan, K.M. Davies, L.K. Keefer, K.M. Miranda*, "HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH", Inorg. Chem., 50, 3262-3270 (2011).
D. Andrei, D.J. Salmon, S. Donzelli, A. Wahab, J.R. Klose, M.L. Citro, J.E. Saavedra, D.A. Wink, K. M. Miranda*, Larry K. Keefer*, "Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class", J. Am. Chem. Soc., 132, 16526-16532 (2010).
T.W. Miller, M.E. Cherney, N. Franco, P.J. Farmer, S.B. King, A.J. Hobbs, K.M. Miranda, J.N. Burstyn, J.M. Fukuto*, "The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols", J. Biol. Chem, 284, 21788-21796 (2009).
S. Donzelli, M.G. Espey, W. Flores-Santana, C.H. Switzer, G.C. Yeh, J. Huang, D. Stuehr, S.B. King, K. M. Miranda, D.A. Wink*, "Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine", Free Radic. Biol. Med., 45, 578-584 (2008).
A.S. Dutton, C.P. Suhrada, K.M. Miranda, D.A. Wink, J.M. Fukuto, K.N. Houk*, "Mechanism of pH dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from Density Functional Theory and CBS-QB3 calculations", Inorg. Chem., 45, 2448-2456 (2006).
K.M. Miranda*, T. Katori, C.L. Torres de Holding, L. Thomas, L.A. Ridnour, W.J. McLendon, S. Cologna, A.S. Dutton, H.C. Champion, D. Mancardi, C.G. Tocchetti, J. Saavedra, L.K. Keefer, K.N. Houk, J.M. Fukuto, D.A. Kass, N. Paolocci, D.A. Wink*, "Comparison of the NO and HNO donating properties of diazeniumdiaolates. Primary amine adducts release HNO in vivo", J. Med. Chem., 48, 8220-8228 (2005).
K.M. Miranda*, H.T. Nagasawa, J.P. Toscano, "Donors of HNO", Curr. Topics Med. Chem., 5, 649-664 (2005).
K.M. Miranda*, A.S. Dutton, L.A. Ridnour, C.A. Foreman, E. Ford, N. Paolocci, T. Katori, D. Mancardi, D.D. Thomas, M.G. Espey, K.N. Houk, J.M. Fukuto, D.A. Wink*, "Mechanism of aerobic decomposition of Angeli’s salt (sodium trioxodinitrate) at physiological pH", J. Am. Chem. Soc., 127, 722-731 (2005).
K.M. Miranda, "The chemistry of nitroxyl (HNO) and implications in biology", Coordin. Chem. Rev., 249, 433-455 (2005).
K.M. Miranda*, N. Paolocci, T. Katori, D.D. Thomas, M.D. Bartberger, M.G. Espey, D.A. Kass, M. Feelisch, J.M. Fukuto, D.A. Wink*, "A biochemical rationale for the orthogonal behavior of nitroxyl and nitric oxide in the cardiovascular system", Proc. Natl. Acad. Sci. USA, 100, 9196-9201 (2003).
N. Paolocci, T. Katori, H.C. Champion, M.E. St. John, K.M. Miranda, J.M. Fukuto, D.A. Wink, D.A. Kass*, "Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from β-adrenergic signaling", Proc. Natl. Acad. Sci. USA, 100, 5537-5542 (2003).
M.D. Bartberger, W. Liu, E. Ford, K.M. Miranda, C. Switzer, J.M. Fukuto*, P.J. Farmer, D.A. Wink, K.N. Houk*, "The reduction potential of nitric oxide (NO) and its importance to NO biochemistry", Proc. Natl. Acad. Sci. USA, 99, 10958-10963 (2002).
K.M. Miranda*, M.G. Espey, D.A. Wink, "A rapid, simple spectrophotometric method for detection of nitrate and nitrite", Nitric Oxide, 5, 62-71 (2001).
K.M. Miranda*, M.G. Espey, K. Yamada, M. Krishna, N. Ludwick, S. Kim, D. Jourd’heuil, M.B. Grisham, M. Feelisch, J.M. Fukuto, D.A. Wink, "Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion", J. Biol. Chem., 276, 1720-1727 (2001).