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Dimitri Antoniou

Research Associate Professor

Degrees and Appointments

  • Ph.D. (Theoretical Condensed Matter Physics) 1991, Indiana University

Applications of statistical physics to chemical and biological systems:
- Effect of fast motions in enzymatic catalysis
- Rare reactive events in enzymes: transition path sampling
- Algorithms for multivariable data analysis of enzymatic motions

 

D. Antoniou and S. Schwartz: Role of protein motions in catalysis by Formate Dehydrogenase, J. Phys. Chem. B 124, 9483 (2020)

I. Zoi, D. Antoniou and S. Schwartz: Linking protein dynamics to enzyme catalysis, in Comprehensive Natural Products III (Chemistry and Biology), vol. 4, p. 587, Elsevier (2020)

J. Schafer, I. Zoi, D. Antoniou and S. Schwartz: Optimization of the turnover in artificial enzymes via directed evolution results in the coupling of protein dynamics to chemistry, J. Am. Chem. Soc. 141, 10431 (2019)

R. Harijan, I. Zoi, D. Antoniou, S. Schwartz and V. Schramm: Inverse enzyme isotope  effects in human purine nucleoside phosphorylase with heavy asparagine labels, PNAS 115, 6209 (2018)

I. Zoi, D. Antoniou and S. Schwartz: Electric fields and fast protein dynamics in enzymes, J. Phys. Chem. Lett. 8, 6165-6170 (2017)

I. Zoi, D. Antoniou and S. Schwartz: Incorporating fast protein dynamics into enzyme design: a proposed mutant aromatic amine dehydrogenase, J. Phys. Chem. B 121, 7290-7298 (2017)

R. Harijan, I. Zoi, D. Antoniou, S. Schwartz and V. Schramm: Catalytic-site design for inverse heavy-enzyme isotope effects in human PNP, Proc.  Nat. Acad. Sci. USA 114, 6456-6461 (2017)

I. Zoi, J. Suarez, D. Antoniou, S. Cameron, V. Schramm and S. Schwartz: Modulating enzyme catalysis through mutations designed to alter rapid protein dynamics, J. Am. Chem. Soc. 138, 3403-3409 (2016)

D. Antoniou and S. Schwartz: Phase space bottlenecks In enzymatic reactions, J. Phys. Chem. B  120, 433-439 (2016)

Z. Wang, D. Antoniou, S. Schwartz and V. Schramm: Hydride transfer In DHFR by transition path sampling, kinetic isotope effects, and heavy enzyme studies, Biochemistry 55, 157-166 (2016)

M. Dzierlenga, Antoniou and S. Schwartz: Another look at the mechanisms of hydride transfer enzymes with quantum and classical Transition Path Sampling, J. Phys. Chem. Lett. 6, 1177-1181 (2015)

I. Zoi, M. Motley, D. Antoniou, V. Schramm and S. Schwartz: Enzyme homologues have distinct reaction paths through their transition states, J. Phys. Chem. B 119, 3662-3668 (2015)

M. Dametto, D. Antoniou and S. Schwartz: Barrier crossing In DHFR does not involve a rate-promoting vibration, Mol. Phys. 110, 531-536 (2012)

D. Antoniou, X. Ge, V. Schramm and S. Schwartz: Mass modulation of protein dynamics associated with barrier crossing on PNP, J. Phys. Chem. Lett. 3, 3538-3544 (2012)