Presented by Dr. Thomas Tomasiak
When
Where
Abstract
The membranes that separate our cells from their external environment are a central component of life. Proteins called transporters play critical roles in membranes because they help build these membranes and control the flow of molecules across them. Our lab uses a combination of imaging techniques and functional assays to show how transporters perform their roles and how they are regulated. This is an especially important process in response to cell stress and plays critical roles in the treatment of pathogens, cancer, and genetic disease. As an example, we have uncovered deep allosteric networks in disordered regions of fungal transporters that contribute the extraordinary resilience of these pathogens. We have also shown how transporters that contribute to metabolic rewiring in cancer are assembled and trafficked with the help of disordered regions. Our work provides new models of allosteric control in transporters useful for the creation of new generation of therapeutic approaches.
Dr. Thomas Tomasiak
Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ
Hosted by: Dr. Bill Montfort