Faculty participating in the program hold appointments in either the Department of Chemistry and Biochemistry, or the Department of Pharmacology and Toxicology.

Faculty Research Interests
Craig A. Aspinwall
Cellular Function at the Interface of Analytical Chemistry and Cell Physiology
Michael Brown
NMR spectroscopy; membrane proteins and lipid bilayers; receptors and biological signaling; vision
Eli Chapman
Pharmacology and Toxicology
Protein-guided therapeutic discovery; Chemical biology to study p97 biochemistry and biophysics; Small-molecule based therapeutic discovery and development
Pascale Charest Chemistry/Biochemistry Signaling mechanisms and directed cell motility
Matthew Cordes
Structural Evolution and Conformational Switching in Proteins
Indraneel Ghosh
Signal Transduction Pathways, Anti-Cancer Agents and Protein Based Biosensors
Richard S. Glass
Mechanistic, Synthetic and Structural Chemistry
Michael Heien Chemistry/Biochemistry Measuring neurotransmitters and neuromodulators.  Specifically to figure out how chemicals affext individual neurons and behavior. The goal of his research is to understand the molecular mechanisms behind synapse formation, the role of supporting cells in modulation of neurotransmission, and how these work to regulate behavior.
Nancy Horton
Macromolecular structure and function; X-ray crystallography
Victor J. Hruby
Asymmetric Synthesis; Biologically Active Peptides/Mimetics; Conformation-Activity Relationships
Christopher Hulme
Enabling chemistries and platform technologies for the construction of targeted small molecule libraries that span possible applications across multiple target families
Laurence H. Hurley
Pharmacology and Toxicology
Development of antitumor agents
John Jewett
Chemical virology - Developing chemical tools to study dengue virus
Eugene A. Mash, Jr.
Organic Synthesis; Medicinal Chemistry; Chemical Toxicology

Michael Marty


Membrane proteins play a number of critical biochemical roles and make up the majority of drug targets. Despite their importance, membrane proteins remain challenging systems for analysis due to their amphipathic nature and low expression levels. Moreover, the lipid bilayer can play an important but largely unexplored role in regulating membrane protein structure and function. New analytical and biochemical methods are necessary to better understand and design drugs to target membrane proteins.
Katrina M. Miranda
Chemical Biology of Nitrogen Oxides; New Detection Techniques and Donors of Nitrogen Oxides; Drug Development
William R. Montfort
Protein structure, function and dynamics; X-ray crystallography
Jon Njardarson Chemistry/Biochemistry Organic synthesis, medicinal chemistry and drug development
Mark Pagel
ARL/Cancer Center
Magnetic Resonance Imaging; assessments of cancer and anticancer therapeutics
Robin L. Polt
Cell-surface Carbohydrates
S. Scott Saavedra
Interfacial Optics, Biofilms, Biosensors

Steve Schwartz Chemistry/Biochemistry

Understanding the atomic reaction coordinate of chemical reactions when catalyzed by enzymes and the function of complex protein motor assemblies.

Catharine L. Smith
Pharmacology and Toxicology
Epigenetic mechanisms of gene expression, their regulation through signaling pathways and modulation by anti-cancer drugs

Deakyu Sun
Pharmacology and Toxicology

Regulation of gene expression with chemicals
Elisa Tomat Chemistry/Biochemistry Biological inorganic chemistry of oxidative stress, wound healing, cell proliferation and cancer


Jun Wang
Pharmacology and Toxicology
Structure, mechanism, and inhibition of ion channels


Georg Wondrak
Pharmacology and Toxicology
Molecular pathways of skin photocarcinogenesis that involve cellular photooxidative and carbonyl stress; Developing chemical reagents into potent drugs that target reactive chemical intermediates
Donna Zhang
Pharmacology and Toxicology
The Nrf2/Keap1 signaling pathway that is activated by oxidative stress and chemopreventive compounds; Regulation of gene expression by the ubiquitination and proteasomal degradation pathway