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UA Invention to Enhance Natural Safeguard Against Skin Cancer

Story by Paul Tumarkin | Photo of Drs. Minying Cai (left) is courtesy of O. Mendoza/CBC; photo of Victor Hruby (right) is courtesy of Paul Tumarkin/Tech Launch Arizona. | Image of a model showing molecular interactions between the melanocortin 1 receptor and the newly designed peptide courtesy of Minying Cai.

UA research results in melanin-producing compound for a systemic approach to preventing skin damage

Tucson, Ariz. – The University of Arizona has licensed two inventions developed in the Department of Chemistry and Biochemistry to startup MCR Therapeutics. The inventors – Drs. Minying Cai and Victor J. Hruby – developed targeted peptides through their research into drug design and bioactivity expression relating to hormone activity in the brain and periphery.

A model showing molecular interactions between the melanocortin 1 receptor and the newly designed peptide. Credit: Minying CaiThe peptides, which are specific for certain melanocortin receptors, represent a leap forward in novel options for skin cancer prevention, detection and treatment. The selective melanotropin peptide stimulates the natural production of skin cells that produce melanin, the pigment responsible for skin color and provides protection against harmful ultraviolet light. Melanocortin receptors are known to play a role in many other physiological aspects such as obesity, stress, cognition and mood. For now, MCR plans to focus first on skin, however these peptides appear to be useful in several other indications.

With 3 million new cases diagnosed each year, skin cancer is one of the most common cancers, with more cases being diagnosed annually than all other cancers. Of those cases, estimates are that 178,560 will be malignant melanoma, and over 9,300 people will die of the disease in 2018 in the U.S. alone.

Traditionally, sunscreens have been used to prevent skin damage from ultraviolet (UV) radiation; the problem is that such sunscreens are often applied incorrectly or incompletely and can easily wash away during outdoor activities when such protection is needed most.

“Furthermore, most sunscreens are only partially effective compared to natural tanning ‘pigmentation,’ which is the basis of our discovery and allows pigmentation without the sun or a tanning salon,” says Dr. Hruby.

The research team worked with Tech Launch Arizona (TLA), the office of the UA that commercializes inventions stemming from UA research, on a number of fronts. Along with collaborating to patent the technologies, they advanced their business plan via the National Science Foundation I-Corps program to apply the "lean launch" method for launching a business and utilize the program grant for customer discovery. They also received TLA Asset Development funding to bring their product closer to market readiness.

The TLA team of experts who helped with the commercialization process included Director of Licensing Rakhi Gibbons and Mentor-in-Residence Mike Sember.

“We’ve worked with Drs. Cai and Hruby on a number of technologies and startups,” said Gibbons. “It’s great to work with a team so dedicated to thinking beyond the lab and ensuring that the products of their research are moving out into the world to create impact.”

Drs. Cai and Hruby each hold appointments in the College of Science and the College of Medicine – Tucson. They are members of the Arizona Cancer Center and the UA BIO5 Institute.

Startup Licenses UA Invention to Enhance Natural Safeguard Against Skin Cancer and Other DiseasesThursday, May 31, 2018