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Victor J. Hruby - Publications

Selected Publications

1181.  Novel μ Agonist, δ Antagonist, and NK1 Antagonist Peptide Chimeras. Isuru R. Kumarasinghe, Victor J. Hruby, S. Tumati, Shou-Wu Ma, Eva Varga, Josephine Lai, and Frank Porreca Breaking Away: Proceedings of the 21st American Peptide Symposium, M. Lebl, Ed., Am. Peptide Soc., San Diego, 179-180 (2009).

1182. Studies of Energy Balance and Cancer. Joel Nyberg, Alexander Mayorov, Minying Cai, Morgan Zingsheim, and Victor J. Hruby. Breaking Away: Proceedings of the 21st American Peptide Symposium, M. Lebl, Ed., Am. Peptide Soc., San Diego, 310-311 (2009).

1183. Functional Studies of AT1 Antagonist SII Analogues Reveal Selective Cell Signaling and Inhibitiion of Ang-II Mediated NHE3 Activation. Minying Cai, H. Xu, Zhihua Liu, Hongchang Qu, J. Li, F.K. Ghishan, and Victor J. Hruby. Breaking Away: Proceedings of the 21st American Peptide Symposium, M. Lebl, Ed., Am. Peptide Soc., San Diego, 300-301 (2009).

1184. Synthesis of Optically Active Anti-β-Substituted γ,δ-Unsaturated Amino Acids via Asymmetric Thio-Claisen Rearrangement. Zhihua Liu, Hongchang Qu, Xuyuan Gu, KuangSu Lee, Bryan Grossman, Vlad K. Kumirov, and Victor J. Hruby. Breaking Away: Proceedings of the 21st American Peptide Symposium, M. Lebl, Ed., Am. Peptide Soc., San Diego, 11-12 (2009).

1185. Sex-Specific Mediation of Opioid-Induced Hyperalgesia by the Melanocortin-1 Receptor. A. Juni, Minying Cai, Magda Stankova, A.R. Waxman, C. Arout, G. Klein, A. Dahan, Victor J. Hruby, J.S. Mogil, and B. Kest. Anesthesiology, 112, 181-188 (2010).

1186. New Insight into the Binding Mode of Cyclic Melanocortin Ligands at the MC4 Receptor. D. Brancaccio, A. Carotenuto, P. Grieco, V.J. Hruby, and E. Novellino. Breaking Away: Proceedings of the 21st American Peptide Symposium, M. Lebl, Ed., Am. Peptide Soc., San Diego, 117-118 (2009).

1187. Melanotropins as Drugs for the Treatment of Obesity and Other Feeding Disorders: Potential and Problems. Minying Cai, Joel Nyberg, and Victor J. Hruby. Curr. Topics Med. Chem., 9, 554-563 (2009).

1188.  Organic Chemistry and Biology: Chemical Biology Through the Eyes of Collaboration (A Perspective).  Victor J. Hruby. J. Org. Chem., 74, 9245-9264 (2009).NIHMSID# 261930

1189. Optimization of Time-Resolved Fluorescence Assay for Detection of Europium-Tetraazacyclododecyltetraacetic Acid-Labeled Ligand-Receptor Interactions. Channa R. De Silva, Josef Vagner, Ronald Lynch, Richard J. Gillies, and Victor J. Hruby. Analytical Biochemistry, 398, 15-23 (2010). NIHMSID 163449

1190. Chemical Synthesis of Peptides and Peptide Libraries. Victor J. Hruby. D. Austin, Ed., Chemical Biology: The Role of Chemistry in Our Fundamental Understanding of Biology, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd., London (2009).

1191. Novel Binding Motif of ACTH Analogues at the Melanocortin Receptors. Y. Yang, Victor J. Hruby, M. Chen, C. Crasto, Minying Cai and C.M. Harmon. Biochemistry, 48, 9775-9784 (2009).

1192. Delta Opioid Receptor Function. Edita Navratilova, Victor J. Hruby and Frank Porreca. The Opiate Receptors. Chapter 12. G. Pasternak, Ed., 2nd ed. Vol. 23. Humana Press. 307-340 (2011).

1193.  Spinal or Systemic TY005, A Peptidic Opioid Agonist/Neurokinin 1 Antagonist, Attenuates Pain with Reduced Tolerance. Tally M. Largent-Milnes, Takashi Yamamoto, Padma Nair, J.W. Moulton, Victor J. Hruby, Josephine Lai, Frank Porreca and Todd W. Vanderah. Brit. J. Pharmacol., 161, 986-1001 (2010).

1194. Synthesis and Characterization of a Eu-DTPA-PEGO-MSH(4) Derivative for Evaluation of Binding of Multivalent Molecules to Melanocortin Receptors. Liping Xu, Josef Vagner, R. Alleti, V. Rao, B. Jagadish, Daid L. Morse, Victor J. Hruby, Richard J. Gillies, and Eugene A. Mash. Bioorg. Med. Chem. Letts., 20, 2489-2492 (2010).

1195.  Fluorescent and Lanthanide Labeling for Ligand Screens, Assays, and Imaging.  Jatinder S. Josan, Channa R. DeSilva, B. Yoo, Ronald M. Lynch, Martin D. Pagel, Josef Vagner, and VictorJ. Hruby. Drug Design and Discovery, Methods in Molecular Biology, S. D.S. Jois and J. Walker, Eds., Methods in Mol. Biol., Vol 716, 89-126 (2011).

1196. Multiple N-Methylationof MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies.  L. Doedens, F. Opperer, Ming Cai, J.G. Beck, Matthew Dedek, Erin Palmer, Victor J. Hruby, and Horst Kessler. J. Amer. Chem. Soc., 132, 8115-8128 (2010). NIHMSID 208710.

1197. Synthesis and Evaluation of New Endomorphin-2 Analogues Containing (Z)-α,β-Didehydrophenylalanine (ΔZPhe) Residues.  D. Torino, Adriano Mollica, F. Pinnen, F. Feliciani, G. Lucente, G. Fabrizi, G. Portalone, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca, and Victor J. Hruby. J. Med. Chem., 53 (11), 4550–4554 (2010).

1198. Novel Strategy for Next Generation Analgesics Without Showing Tolerance.  Takashi Yamamoto, Tally M. Largent-Milnes, Padma Nair, Peg Davis, Shou-Wu Ma, Josephine Lai, Henry I. Yamamura, Todd W. Vanderah, Frank Porreca, and Victor J. Hruby. Peptide Science 2009, K. Okamoto, Ed., The Japanese Peptide Society, 91-92 (2010).

1199.  Novel Anti-β-Functionalized γ,δ-Unsaturated Amino Acids Via a Thio-Claisen Rearrangement.  Zhihua Liu, Hongchang Qu, Xuyuan Gu, Kuang-Su Lee, Bryan Grossman, Vlad K. Kumirov, and Victor J. Hruby. Tetrahedron Letters, 51, 3518-3520 (2010).

1200.   Identification of Novel Pancreatic Adenocarcinoma Cell-Surface Targets by Gene Expression Profiling and Tissue Microassay. David L. Morse, Yoga Balagurunathan, Galen Hostetter, Maria Trissal, Narges K. Tafreshi, Nancy Burke, Mark Lloyd, Steven Enkemann, Domenico Coppola, Victor J. Hruby, Robert J. Gillies, and Haiyong Han. Biochem. Pharmacol., 80, 748-754 (2010).

1201.   Design and Synthesis of Trivalent Ligands Targeting Opioid, Cholecystokinin, and Melanocortin Receptors for the Treatment of Pain. YeonSun Lee, Steve Fernandes, Vinod V. Kulkarni, Alexander Mayorov, Peg Davis, Shou-Wu Ma, K. Brown, Robert J. Gillies, Josephine Lai, Frank Porreca, and Victor J. Hruby.  Bioorg. Med. Chem Letts., 20, 4080-4084 (2010). NIHMSID 213620.

1202. Biological Conformational Evaluation of Bifunctional Compounds for Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists Possessing Two Penicillamines. Takashi Yamamoto, Padma Nair, Neil E. Jacobsen, Vinod Kulkarni, Peg Davis, Shou-Wu Ma, Edita Navratilova, Henry I. Yamamura, Todd W. Vanderah, Frank Porreca, Josephine Lai, and Victor J. Hruby. J. Med. Chem., 53, 5491-5501 (2010). PMC:20617791. NIHMS220760.

1203. Solid-Phase Peptide Head-to-Side Chain Cyclodimerization: Discovery of C2-Symmetric Cyclic Lactam Hybrid α-Melanocyte-Stimulating Hormone (MSH)/Agouti-Signaling Protein (ASIP) Analogues with Potent Activities at the Human Melanocortin Receptors. Alexander V. Mayorov, Minying Cai, Erin S. Palmer, Zhihua Liu, James P. Cain, Josef Vagner, Dev Trivedi, and Victor J. Hruby. Peptides, 31, 1894-1905 (2010). PubMed #20688117. NIHMS236189.

1204. New Potent Biphalin Analogues Containing p-Fluoro-L-phenylalanine at the 4,4’ Positions and Non-hydrazine Linkers. Adriano Mollica, Francesco Pinnen, Federica Feliciani, Azzurra Stefanucci, Gino Lucente, Peg Davis, Frank Porreca, Shou-Wu Ma, Josephine Lai, and Victor J. Hruby.  Amino Acids 40, 1503-1512 (2010).

1205. Synthesis and Activity of Endomorphin-2 and Morphiceptin Analogues with Proline Surrogates in Position 2. Cesare Giordano, Anna Sansone, Annalisa Masi, Gino Lucente, Pasqualina Punzi, Adriano Mollica, Francesco Pinnen, Federica Feliciani, Ivana Cacciatore, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca, and Victor J. Hruby. European J. Med. Chem., 45(10) 4591-4600 (2010).

1206. Utilize Conjugated Melanotropins for the Earlier Treatment and Diagnosis of Melanoma.  Minying Cai, Zhihua Liu, Hongchang Qu, Helen Fan, Zhiping Zhang, and Victor J. Hruby.  European J. Pharmacol., 660, 188-193 (2011).

1207. Methods of Identifying Pancreatic Cancer Cells. Victor J. Hruby, Haiyong Han, Robert J. Gillies, and David L. Morse. U.S. Patent Number 7,816,082 (2010).

1208. Design of Novel Melanocortin Receptor Ligands:  Multiple Receptors, Complex Pharmacology: The Challenge. Victor J. Hruby, Minying Cai, James Cain, Joel Nyberg, and Dev Trivedi.  Eur. J. Pharmacol., 660, 88-93 (2011).

1209. Collaboration Between Chemists and Biologists. Victor J. Hruby. Collaborative Computational Technologies For Biomedical Research, S. Ekins, M.A. Hupcey and A.J. Williams, eds., John Wiley & Sons, Hoboken, NJ, Chapter 7, 113-120  (2011).

1210. Proton Sharing and Transfer in Some Zwitteronic Compounds Based on 4-Oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino) alcanoic Acids. Gary S. Nichol, Vlad K. Kumirov, Ruben Vardanyan, and Victor J. Hruby. Cryst. Eng. Commun., 12, 3651-3657(2010).

1211. Development of Potent μ and δ Opioid Agonists With High Lipophilicity. YeonSun Lee, Vinod Kulkarni, Scott M. Corwell, Shou-Wu Ma, Peg Davis, Katherine E. Hanlon, Todd W.Vanderah, Josephine Lai, Frank Porreca, Ruben Vardanyan, and Victor J. Hruby.  J. Med. Chem.,54, 382-386 (2011). NIHMSID #256737

1212. Syntheses and Crystallographic Study of N1-(1-Benzyl-piperdin-4-yl) acetohydrazide. Gary S. Nichol, Ruben Vardanyan, and Victor J. Hruby. J. Chem. Crystallogr., 40, 961-961(2010).

1213. Letter to Editor – Bovine Insulin Synthesis. Victor J. Hruby.  Chem. & Eng. News, 88, 6(2010).    

1214. Discovery of a Potent And Efficacious Peptide Derivative For δ/μ Opioid Agonist/Neurokinin 1 Antagonist Activity With a 2',6'-Dimethyl-L-Tyrosine: In Vitro, In Vivo, and NMR-Based Structural Studies. Takashi Yamamoto, Padma Nair, Tally M. Largent-Milnes, N.E. Jacobsen, Peg Davis, Shou-Wu Ma, Henry I. Yamamura, Todd W. Vanderah, Frank Porreca, Josephine Lai, and Victor J. Hruby J. Med. Chem., 54 (7), 2029–2038 (2011). PMID:21366266

1215. Bifunctional Analgesic Compounds for Opiod Receptor Agonists and Neurokinin-1 Receptor Antagonists. Victor J. Hruby, Padma Nair, and Takashi Yamamoto. U.S. Patent 8026128 Chem. abstr. 148 567898, Issued Sept, 27 (2011).

1216. Cyclic Lactam Hybrid α-MSH/Agouti-Related Proteins (AGRP) Analogues with Nanomolar Range Binding Affinities at the Numan Melanocortin Receptors. Alexander V. Mayorov, Minying Cai, Erin S. Palmer, D.K. Tanakas, James R. Cain, Matthew M. Dedek, Bhar Tan, Dev Trivedi and Victor J. Hruby. Bioorg. Med. Chem. Letters, 21, 3099-3102 (2011) . PMCID:PMC3216836 

1217. Approaches to the Rational Design of Selective Melanocortin Receptor Antagonists.  Victor J. Hruby, Minying Cai, Joel Nyberg, and Dhanasekaran Muthu. Expert Opinion on Drug Discovery, 6(5), 543-557 (2011).   

1218. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.  Katherine E. Hanlon, Dave S. Herman, Richard S. Agnes, Tally M. Largent-Milnes, Isuru R. Kumarasinghe, Shou-Wu Ma, Wenhong Guo, Yeon-Sun Lee, Michael H. Ossipov, Victor J. Hruby, Josephine Lai, Frank Porreca, Todd W. Vanderah. Brain Res. 1395: 1–11 (2011). PMCID: PMC3105124

1219. Backbone Alignment Modeling of the Structure-Activity Relationships of Opioid Ligands. Zhijun Wu and Victor J. Hruby. J. Chem. Inf. Model. 51, 1151-1164 (2011).

1220. Synthesis and Evaluation of New Opioid and Neurokinin-1Antagonist Bivalent Ligands. Ruben Vardanyan, Vlad K. Kumirov, Gary S. Nichol, Peg Davis, Erik Liktor-Busa, David Rankin, Eva Varga, Todd W. Vanderah, Frank Porrecca, Josephine Lai. and Victor J. Hruby. Bioorg. Med. Chem, 19(20), 6135-6142 (2011).

1221. Modification of Peptides to Limit Metabolism. Isuru R. Kumarasinghe and Victor J. Hruby. Peptide Drugs: Peptide Chemistry and Drug Design, B. Dunn, Editor, John Wiley & Sons, New York, in press (2011).

1222. Cell Specific Targeting by Heterovalent Ligands. Jatinder S. Josan, Heather L. Handl, Rajesh Sankanaryanan, Liping Xu, Ronald M. Lynch, Jsef Vagner, Eugene A. Mash, Victor J. Hruby and Robert J. Gillies. Bioconjugate Chemistry, 22, 1270-1278 (2011).

1223. Development of Non-Opioid Dynorphin A Analogs for the Modulation of Pain. YeonSun Lee, David Rankin, Brianna Paisely, Sara M. Hall, Dhanasekaran Muthu, J.J. Ortiz, Frank Porreca, Josephine Lai and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 348-349 (2011).

1224. Design, Synthesis and Study of New Multimeric Ligands -Application as Vectors for Cancer Diagnosis and Therapy. Nabila Brabez, Liping Xu, Robert J. Gillies, Ronald M. Lynch, Gerard Chassaing, Solange Lavielle and Victor J. Hruby.  Peptides: Building Bridges; Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 240-241 (2011).

1225. Design Strategies to Produce Receptor Subtype Selective Peptide Agonists and Antagonists for Melanocortin Receptor System. Dhanasekaran Muthu, Robert Soto, Minying Cai, YenShan Lim, Dev Trivedi and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 332-333 (2011).

1226. Synthesis of Analogue of a-MSH for Targeting of Melanocortin Receptors—Copper-Free Click Chemistry Approach. Alexander Kuzmin, Josef Vagner, Natalie Barkey, David Morse, Robert Gillies and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 338-339 (2011).

1227. Novel Designed Melanotropins Lead to Selective Cell Signaling. Minying Cai, James P. Cain, Jennifer M. Bao, Dhanasekaran Muthu, Devendra Trivedi and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 334-335 (2011).

1228. Synthesis and Investigations of Peptidic-Non-Peptidic Bivalent Ligands for Treatment of Pain. Ruben Vardanyan, YeonSun Lee, James P. Cain, Peg Davis, Todd W. Vanderah, Josephine Lai, Frank Porreca and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 358-359 (2011).

1229. Design and Synthesis of Novel Bifunctional Ligands (Opioid Agonist and Bradykinin Antagonist) for Treatment of Chronic and Neuropathic Pain. Srinivas Deekonda, David Rankin, Peg Davis, Josephine Lai, Frank Porreca and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 350-351 (2011).

1230. Energy Balance Studies and Cancer. Joel Nyberg, Minying Cai, Kimberly Osesky and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, San Diego, 360-361 (2011).

1231. Microwave Assisted Lacatam Cyclization of Peptides. Vinod V. Kulkarni, Nabila Brabez, Christine Salibay, Heather Harteis and Channa DeSilva. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 338-339 (2011).

1232. Incorporation of Beta-amino Acids in MT-II and SHU9119. Vinod V. Kulkarni, Minying Cai, Dhanasekaran Muthu and Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 336-338 (2011).

1233. Adventures in Peptides and Science With Students! The Joys of Research. Victor J. Hruby. Peptides: Building Bridges; Proceedings of the 22nd Am. Peptide Symp., M. Lebl and R. Storey, Eds., Am. Peptide. Soc., San Diego, 31-35 (2011).

1234. Recyclization Reactions of 1-alkylpyrimidinium Salts. Ruben S. Vardanyan, Gevork G. Danagulyan, Armen D. Mkrtchyan, and Victor J. Hruby. Heterocyclic Communications. 17(3-4),129–133, (2011).

1235. Design, Synthesis, and Biological Studies of Efficient Multivalent Melanotropin Ligands: Tools toward Melanoma Diagnosis and Treatment. Nabila Brabez, Ronald M. Lynch, Liping Xu, Robert J. Gillies, Gerard Chassaing, Solange Lavielle, and Victor J. Hruby.  J. Med. Chem. 54 (20), 7375-7384, (2011).

1236. Improved Synthesis of  D, L-Fluorocitric Acid. Ruben Vardanyan, Vlad K. Kumirov and Victor J. Hruby. J. Fluorine Chemistry, 132, 920-924 (2011).

1237. Development of Melanoma Taregeted Polymer Micells By Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand. Natalie M. Barkey, N K. Tafreshi, Jatinder S. Josan, Channa R. DeSilva, Kevin N. Sill, Victor J. Hruby, Robert J. Gillies, David L. Morse, and Josef Vagner. J. Med. Chem., 54(23), 8078-8084 (2011).

1238. The Cis-4-Amino-L-Proline Residue As a Scaffold For the Synthesis of Cyclic and Linear Endomorphin-2 Analogues. Adriano Mollica, Francesco Pinnen, Azzurra Stefanucci, Federica Feliciani, Cristina Campestre, Luisa Mannina, Anatoly P. Sobolev, Gino Lucente, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca, and Victor J. Hruby. J. Med. Chem. 55(7), 3027-35 (2012). PMID: 22394120  

1239.  Synthesis and Biological Evaluation of New Opioid Agonist and Neurokinin-1 Antagonist Bivalent Ligands. Ruben Vardanyan, Vlad K. Kumirov, Gary S. Nichol, Peg Davis, Erika Liktor-Busa, David Rankin, Eva Varga, Todd Vanderah, Frank Porreca, Josephine Lai, Victor J. Hruby. Bioorg. Med. Chem. 19(20), 6135-42 (2011).

1240. Thio-Claisen Rearrangement Used in Preparing Anti-β-Functionalized γ,δ-Unsaturated Amino Acids: Scope and Limitations. Zhihua Liu, Sukeshi J. Mehta, Kwang-Soo Lee, Bryan Grossman, Hongchang Qu, Xuyuan Gu, Gary S. Nichol, Victor J. Hruby. J. Org. Chem. 77(3):1289-300 (2012). PMID: 22283513

1241. Conformational Study on Cyclic Melanocortin Ligands and New Insight into Their Binding Mode at the MC4 Receptor. Paulo Grieco, Diego Brancaccio, Ettore Novellino, Victor  J. Hruby, and Alfonso Carotenuto. Eur. J. Med. Chem. 46(9):3721-33 (2011). PMID: 21652123

1242. Biological and Conformational Evaluation of Bifunctional Compounds for Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists Possessing Two Penicillamines.  Takashi Yamamoto, Padma Nair, Neil E. Jacobsen, Vinod Kulkarni, Peg Davis, Shou-wu Ma, Edita Navratilova, Henry I. Yamamura, Todd W. Vanderah, Frank Porreca, Josephine Lai, Victor J. Hruby. J. Med. Chem.  53(15), 5491–5501 (2010). PMCID: PMC2943425

1243. Strategies for Asymmetric Syntheisis of Amino Acids with γ,δ-Unsaturation. Zhihua Liu, Sukeshi J. Mehta, and Victor J. Hruby. Org. Prep. and Proc. Intl. 44, 222-255 (2012). 

1244.  Letter to the Editor: Global Warming. Victor J. Hruby. Chem. & Eng. News 89(51), 5 (2011).
 

1245. The cis-4-Amino-L-proline Residue as a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2. Adriano Mollica, Francesco Pinnen, Azzurra Stefanucci, Luisa Mannina, Anatoly P. Sobolev, Gino Lucente, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca, and Victor J. Hruby, J. Med. Chem., 55, 8477-8482  (2012). 

1246.   Novel Approaches to the Design of Novel Multivalent Ligands for the Detection and Treatment of Cancer. V.J. Hruby, N. Brabez, C. De Silva, J. Vaquel, D Morse, R.J. Gillies and S. Lavielle. Peptides 2012, Proceedings of the 32nd.European Peptide Symposium, In Press (2012).

1247. Design of Peptide and Peptidomimetic Ligands with Novel Pharmacological Activity Profiles. Victor J. Hruby and Minying Cai. Ann. Reviews of Pharmicol. and Toxicol., In Press (2012).

1248. Heterobivalent Ligands Target Cell- Surface Receptor Combinations In Vivo. Liping Xu, Jatinder S. Josan, Josef Vagner, Michael R. Caplan, Victor J. Hruby, Eugene Mash, Ronald M. Lynch, David L. Morse and Richard J. Gillies. Proc. Nat. Acad. Sci. U.S.A. In Press (2012).

1249. Selective Cell Signaling Study of GPCR for PWRSpectroscopy. Minying Cai, Han Zhang, Matt M. Dedeks, S.S. Saavedra and V.J. Hruby. Peptides 2012, Proceedings of the 32nd European Peptide Peptide Symposium, In Press (2012).

1250. Adventures in Peptides and Science with Students! The Joys of Research. Victor J. Hruby. Biopolymers: Peptide Science, In Press (2012)

1251. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers – Tools for Melanoma Targeting. Nabila Brabez, Kara Saunders, Kevin Nguyen, Thanuja Jayasundera, Craig Weber, Ronald Lynch, Gerard Chassaing, Solange Lavielle, and Victor J. Hruby. J. Med. Chem. Letts, In Press (2012).

1252. α-Melanocyte Stimulating Hormone Regulates Vascular NO Availability and Protects. Against Endotheliol DysfunctionPetteri Rinne, Wendy Nordlund, Ilkka Heinonen, Anna-Maija Penttinen, Antti SarasteSuvi T. Ruohonen, Satu MäkeläLaura Vähätalo, Katja Kaipio, Minying Cai, Victor J. Hruby, Saku Ruohonen and Eriika Savontaus. Cardiovascular Research. In Press (2012).

1253. New Paradigms for Drug Discovery and Development: Design of Multivalent Ligands for the Treatment of Disease. V.J. Hruby, T. Yamamoto, P. Nair, M. Cai, J. Vagner, J.S. Josan, R.J. Gillies, L. Xu, D. Morse, P. Davis, S-W. Ma, T. Largent-Milnes, J. Lai, E. Varga, T. Vanderah, F. Porreca. Peptides: Biology and Chemistry. Proceedings of the 2012 Chinese Peptide Symposium, (EDITORS) In Press (2012).

1254. N-Methylation of Cyclized Melanotropin Peptides: A New Perspective of Drug Discovery for the Melanocortin System. M. Cai, J. Bao, N.R. Zingsheim, J.G. Beck, F. Opperer, L. Doedens, H. Kessler, and V.J. Hruby. Peptides: Biology and Chemistry. Proceedings of the 2012 Chinese Peptide Symposium, (EDITORS) In Press (2012).

1255. Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activations. Suneeta Tumati., Tally M. Largent-Milnes, Attila I. Keresztes, Takashi Yamamoto, Todd W. Vanderah, William R. Roeske, Victor J. Hruby, Eva V. Varga. . European Journal of Pharmacology, Volume 684, Issues 1–3, 64-70 (2012).

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