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Victor J. Hruby, Ph.D. | Table Of Contents |
Regents Professor Emeritus Department of Chemistry and Biochemistry University of Arizona Office: 213/215 Chemistry Building Phone: (520) 621-2162 Email: hruby |
Education, Academic Appointments, Areas of Interest, |
Education
University of North Dakota - B.S. 1960 - Chemistry, Mathematics
University of North Dakota - M.S. 1962 - Chemistry
Thesis Title: "The Chemistry of Sulfur Ylids"
Thesis Director: Dr. A. William Johnson
Cornell University - Ph.D. 1965 - Chemistry
Dissertation Title: "Some Aspects of Benzocyclobutene and Benzocyclobuta-diene Chemistry"
Dissertation Director: Dr. Alfred Blomquist
Academic Appointments
Instructor: Department of Biochemistry, Cornell University
Medical College, New York, New York, 1965-1967; Research Director: Dr. Vincent du Vigneaud
Research Associate: Department of Chemistry, Cornell University
Ithaca, New York, 1967-1968; Research Director: Dr. Vincent du Vigneaud
Assistant Professor: Department of Chemistry, University of Arizona
Tucson, Arizona, 1968-1972
Associate Professor: Department of Chemistry, University of Arizona
Tucson, Arizona, 1972-1977
Guest Worker: National Institutes of Health, Bethesda, Maryland
1975-1976; Sabbatical with Dr. Martin Rodbell
Professor: Department of Chemistry, University of Arizona
Tucson, Arizona, 1977-present
Regents Professor: Department of Chemistry, University of Arizona
Tucson, Arizona, 1989-2008
Professor: Department of Biochemistry, University of Arizona
(Joint Appointment) Tucson, Arizona, 1978-2008
Regents Professor: Department of Chemistry and Biochemistry, University of Arizona
(Joint Appointment) Tucson, Arizona, 2008-present
Professor: Arizona Research Laboratories, University of Arizona
(Joint Appointment) Tucson, Arizona, 1981-present
Professor: Program in Neuroscience, University of Arizona
(Joint Appointment) Tucson, Arizona, 1988-present
Professor: Department of Medical Pharmacology, University of Arizona
(Joint Appointment) Tucson, Arizona, 2005-present
Professor: BIO5, University of Arizona
(Joint Appointment) Tucson, Arizona, 2005-present
Rector's Lecturer: Free University of Brussels
Brussels, Belgium, 1979. Sponsors: Educational Commissions - Fulbright-Hays
Visiting Professor: Harvard University, Department of Chemistry
Cambridge, Massachusetts, 1984-1985 (Guggenheim Fellow). Sabbatical with Dr. Martin Karplus
Visiting Professor: California Institute of Technology, Department of Chemistry
Pasadena, California, 1992. Sabbatical with Dr. Peter Dervan
Visiting Professor: Technical University of Munich, Department of Chemistry and Biochemistry
Garshing, Germany, 1999-2000 (Senior Humboldt Fellow). Sabbatical with Dr. Horst Kessler
Areas of Interest
- Physical/Chemical Basis for Information Transduction
- Host-Guest Relationships
- Peptide Hormone and Neurotransmitter Structure-Function
- Brain Chemistry
- Relation of Conformation to Biological Activity
- Amino Acid, Peptide and Protein Organic Synthesis
- NMR as a Structural Tool for Peptides and Proteins
- Peptides and Cancer - Multimeric Ligands
- Mechanisms of Hormone and Neurotransmitter Actions
- Peptides in the Central Nervous System and Gut - Peptides and Behavior
- Bioorganic Chemistry
- Molecular Mechanics and Molecular Dynamics of Peptides
- Peptide and Peptidomimetic Drug Design
- Asymmetric Synthesis
- Peptide G-Protein Coupled Receptors
- Peptide and Other Chemical Libraries
- Peptides and Cancer Therapy
- Combinatorial Chemistry
- Pain and Drug Abuse
- Topographical Considerations in Molecular Recognition
- De Novo Design of Peptide Mimetics
- The Chemical Basis for Behavior
- Obesity and Anorexia
- Pigmentation
- Erectile Function
Awards, Honors and Fellowships
1959-1960 Abbott Award; Coon Award; Magna cum laude; University of North Dakota
1961 NSF Summer Fellow; University of North Dakota
1962 Sigma Xi; University of North Dakota
1965 NSF Cooperative Fellow; Cornell University
1972 American Association Advancement of Science - Fellow
1974 American Institute of Chemists - Fellow
1975-1976 U.S. Public Health Service Senior Research Fellowship; NIH
1978-1979 Rector's Lectureship; Free University of Brussels
1979 Fulbright-Hays Fellow
1979 Pfizer Lecturer, Clinical Research Institute of Montreal
1979 University Lecturer; University of Baghdad
1981 New York Academy of Science – Fellow
1981-1982 UNESCO Lecturer; Bangalore, India
1983 Welsh Lectureship
1984 Karger Lectuerer; University of Oklahoma
1984 Distinguished Alumni Lecturer; University of North Dakota
1984-1985 Guggenheim Fellowship
1985 University Lecturer; University of Texas
1986 American Diabetes Association Research Award
1986 DuPoint Distinguished Lecturer; University of Indiana
1987 Javits Neuroscience Award
1988-1996 MERIT Award – NIH
1988 Merritt-Putnam Lecturship
1989 Doctor Honorus Causa; Free University of Brussels
1989 Regents Professor; University of Arizona
1989 Selectide Corporation- Founder
1991 University Distinguished Lecturer; Creighton University
1993 Pierce (ne Merrifield) Award (APS)
1996 Bloomquist Lecturer, Cornell University
1999-2000 Humboldt Senior Scientist Award - Fellow
2000 Sieman’s Lecturer, Germany
2001 Tetrahedron - Guest Editor (with Vadim Soloshonok). Asymmetric Synthesis of Novel Sterically Constrained Amino Acids
2002 Ralph T. Hirschmann Award (ACS)
2002 Cathay Award (China)
2003 Karcher Lectuer; Univeristy of Oklahoma
2003 Abbott Lectuerer; University of North Dakota
2003 Nolan and Gloria Sommer Award
2005 Arizona Art, Science & Technology Academy
2006 Eminent Scholar Lecture; University of Arizona
2006 Distinguished Career Teaching Award; University of Arizona
2006 Anniversary Medal; Polish Academy of Sciences
2007 Goodman Lecturer; University of California San Diego
2009 Arizona Technology Innovator of the Year; University of Arizona
2009 Arthur C. Cope Scholar Award (ACS)
2010 Boehringer Ingelheim Lecturer; University of Montreal
2011 Murray Goodman Scientific Excellence Mentorship Award (APS)
Teaching Responsibilities
Chemistry 540 - Organic Synthesis 1968-1977
Chemistry 543 - Organic Structure Determination 1969-present
Chemistry 299, 399, 499 - Honors (Undergraduate Research 1969-present
Chemistry 241a,b - Organic Chemistry 1973-1991
Chemistry 241a,b - Honors) (Organic Chemistry 1970-1973
Chemistry 245a,b - Organic Chemistry Laboratory-Majors 1970-1974
Chemistry 101b - Lectures in General Chemistry 1973, 2001
Chemistry 446 - Organic Preparations 1977, 1987-1991
Chemistry 440 - Qualitative Organic Analysis) 1980, 1986, 1987, 1989, 1991,1995
Biochemistry - Proteins, Enzymes, and Physical Biochemistry 1978, 1980, 1982
Biochemistry - Biophysical Methods 1985-1988
Chemistry 402/502 - Intermediate Organic Chemistry 1985, 1986, 1996, 1997, 1998, 2002, 2003
Chemistry 696C - Organic Seminar 1985, 1986, 1992, 1996
Chemistry 646X & 549A - Peptide and Protein Chemistry 1990, 1994, 1997, 2000, 2009
Chemistry 436, 536 - Scientific and Ethical Aspects of ModifyingHuman Behavior 2004, 2006, 2008, 2010
Courses Developed
Chemistry 543 Organic Structure Determination
Chemistry 245a; 245b Organic Chemistry Laboratory
Chemistry 440 Organic Qualitative Analysis
Chemistry 646 Peptide and Protein Chemistry
Chemistry 402/502 Intermediate Organic Chemistry
Chemistry 436/536 Scientific and Ethical Aspects of Modifying Human Behavior
Departmental Committees
1968-1973 Seminar Committee; Chairman (1969-1973)
1968-1973 Safety Committee; Ad Hoc Committee on Laboratory Renovations (1971-1972)
1973-1975 Travel and Recruiting Committee; Chairman
1973-1975 Undergraduate Advisor
1976-1978 Graduate Study Committee; Chairman (1977-1978)
1978-1979 Faculty Search Committee; Chairman, (1978-1980, 1985-1988)
1979-1999 NMR Committee
1979-1982 Research Committee
1980 Ad Hoc Committee on Faculty Recruiting
1981-1983 Ad Hoc Committee on Faculty Recruiting, Space Committee
1981-1988 Steering Committee; Head, Organic Division (1982-1986)
1983-1992 Promotion and Tenure (For Different Professors)
1984-present Faculty Advisory Committees For Asst. Professors
1988-1990 Research Committee
1988-1990 Department Head Search; Chairman
1990-2005 Computer Graphics Facility
1991-1992 Safety Committee
1995-1999 Computer Graphics Facility Committee; Chairman
1999-present Promotion and Tenure (For Different Professors)
2000-2004 Computer Graphics Facility Committee; Chairman
2003-2010 Faculty Search Committee; Chair
2003-present Committee for Faculty Hiring Plan; Chair
2007-present Faculty Research Committee
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University Committees
1971-1975 University Conciliation Panel Head
1976-1980 University Committee on Graduate Study
1979-1983 Pre-Health Professional Committee
1981-1984 Liberal Arts College Promotion and Tenure Committee; Chairman (1982-1983)
1981-present Arizona Research Laboratory Member
1982-1983 Department Head Search Committee, Chemistry
1982-1985 Biotechnology Committee
1983-1987 Sequencing Facility
1986-1990 Technology Transfer Committee
1987-1993 User Group Committee, Molecular Biology Support Facility, Biotechnology Center
1987-1996 User Group Committee, Molecular Design Facility, Biotechnology Center
1987-1990 University Promotion and Tenure Committee
1989-1991 University Committee on Ethics and Commitment; Acting Chair (1990-1991)
1988 University Committee to Evaluate the Department of Nutrition and Food Science
1989 Faculty of Science Committee to Evaluate Dean
1990-1991 Research Policy Committee
1994-1997 Committee on Academic Freedom and Tenure
1994-2002 Biology 21 Committee
1994-1996 Organizing Principles Committee
1997-2001 Faculty Chair’s Task Force on Faculty Salaries
1998 Undergraduate Centennial Achievement Award Committee
2001-present Biological Chemistry Program Co-Chair
2001-2004 Biotechnology Search Committee
2003-2004 Institute for Biomedical Science and Biotechnology
2005-present Executive Committee - ARIBI
National Committees
1977-present Public Health Service Consultant, Site Visits, Ad Hoc
1979-1990 National Executive Committee, American Peptide Symposium
1980-1984 Physiological Chemistry Study Section, NIH
1981-1983 Chairman, American Peptide Symposium
1985-1989 Secretary, American Peptide Symposium
1985-1989 Bioorganic and Natural Products Chemistry Study Section, NIH
1988-2004 Committee of Editors of Biochemical Journals, IUPAC
1988-1994 Grants Program Advisory Board, Research Corporation
1988-1993 American Chemical Society, Canvassing Committee, Hirschmann Award
1990-1991 American Peptide Society, Council - President
1991-1993 American Peptide Society, Liaison Committee - Chair
1993-1994 NRC Study Committee, Stress in Science, U.of A. Faculty Representative
1993-1995 du Vigneaud Award Committee
1994-1997 American Chemical Society, Medicinal Chemistry - Councilor
1995-1997 Awards Committee, Chair, APS
1996-1998 American Peptide Society, Awards Committee, Chair
1997-2003 American Peptide Society, Council
1997-2001 Cathay Award
2000-2005 Special Emphasis Panel, Molecular Neuropharmacology & Signaling Committee
2007-2012 Special Emphasis Panel, Drug Discovery for the Nervous System
2012-present Special Emphasis Panel, Drug Discovery for the Nervous System
Professional Activities
American Chemical Society
Joint Board-Council Committee on Patents and Related Matters 1997-2010
Academic Councilor-Medicinal Chemistry 1994-2000
Alternate Councilor - Medicinal Chemistry 1997-2001
Ethics Committee 2010-present
Southern Arizona Section
Secretary 1972
President-Elect 1973
President 1974
American Institute of Chemists, Fellow
American Association for Advancement of Science, Fellow
New York Academy of Science, Fellow
Society of Sigma Xi
American Society of Biochemistry and Molecular Biology
Biophysical Society
American Peptide Symposium
President 1982-1984
Vice President 1984-1985
Secretary 1985-1989
Marvel Symposium, Chairman 1987
International Union of Pure and Applied Chemistry 1989-present
Selectide Corporation, Founding Scientist 1990
Scientific Advisory Board, Chairman 1991-1995
American Peptide Society
President 1990-1991
Liaison Committee 1991-1993
Honorary Member 1993-present
Awards Committee, Chairman 1996-1999
Publications Committee 1995-2003
Council 1997-2003
Protein Society 1990-present
The International Neuropeptide Soceity Board 1994-present
The Cathay Award International Committee 1996-2001, 2006-2010
Keystone Symposium, Chairman and Organizer with Gary Olson, Peptide Mimetics 1992
Task Force for Review of Journal of Medicinal Chemistry 1998-1999
Organizing Committees
Am. Peptide Symposium 1997-1999
Chinese Peptide Symposium 1995-present
Intl. Peptidomimetic Symposium 1990-2002
Gordon Research Conference on Peptide Chemistry and Biology, Co-Chair 2002
Editorial Activities
Editor-in-Chief The Journal of Peptide Research 1997-present
Editor-in-Chief International Journal of Peptide and Protein Research 1988-1996
Associate Editor International Journal of Peptide and Protein Research 1981-1988
Editorial Boards Journal of Protein Chemistry 1981-2005
Life Sciences 1984-1990
Journal of Medicinal Chemistry 1987-1991
Peptide Research 1988-2006
Journal of Receptor and Signal Transduction Research 1991-2006
Peptide Science 1993-present
Drug Design and Discovery 1993-present
Current Topics in Medicinal Chemistry 1994-present
Heterocyclic Communications 1994-present
Combinatorial Chemistry and High Throughput Screening 1997-present
I Drugs, The Investigational Drugs Journal 1998-present
Chemical Biol & Drug Design 2006-present
Drug Design, Development & Therapy 2007-present
Open Medicinal Chemistry Journal 2007-present
Biologics: Targets & Therapy 2006-present
Drug Design, Development & Treatment 2007-present
Drug Design & Reviews Online 2003-present
Peptides 2010-present
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- Journal of the American Chemical Society
- Journal of Organic Chemistry
- Science
- Biochemistry
- Proceedings of the National Acadademy of Science U.S.A.
- Biopolymers
- Organic Magnetic Resolution
- Life Sciences
- Journal of Mededicinal Chemistry
- Tetrahedron Letters
- Tetrahedron
- Bioorganic & Medicinal Chemistry Letters
- Organic Letters
- Nature
- Angew. Chemie
- Several other Biological Journals
External Consulting
U.S.
COBRE, NDSU 2001-2006
Several chemical and biotechnology companies (currently three) 1975-present Public Health Service 1977-present
People in Research Group
Research Professors - 2
Postdoctorals - 3
Graduate Students - 7
Research Scientists - 1
Undergraduate Students - 8
Visiting Scientists - 1
Publications
Over 1200 papers in refereed journals, monographs and proceedings – see Publications
Over 400 abstracts from meetings and symposia
Editor of 3 books
Co-author of 1 book
Over 15 patents