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Senthil K. Ganesan

Research Assistant Professor, Chemistry and Biochemistry - Med (Career Track)

Degrees and Appointments

  • Ph.D (Biological Sciences) 2009, Indian Institute of Science, Bangalore, India
  • MSc (Chemistry) 2002, Madurai Kamaraj University, India

Awards and Honors

  • 2012 - Science and Engineering Research Board, Government of India, INSA-Inspire Faculty Fellowship
  • 2002-2007 University Grants Commission, Government of India, Junior and Senior Research Fellowship

My research focuses on the atomic level characterization of protein-protein interactions involved in cell signaling pathways to understand how protein structure and dynamics is correlated to its function. My approaches include the combination of solution NMR spectroscopy, X-ray crystallography, SAXS, ITC and other biochemical/biophysical techniques.

Full list

Bertran, M.T., Mouilleron, S., Zhou, Y., Bajaj, R., Uliana, F., Kumar, G.S., van Drogen A., Lee, R., Banerjee, J.J., Hauri, S., O’REilly, N., Gstaiger, M., Page, R.  Peti, W. Tapon, N. (2019) ASPP protein discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail, Nat. Commun. 10(1), 771.

Kumar, G.S., Page, R., Peti, W. (2019) Preparation of phosphorylated proteins for NMR spectroscopy, Methods Enzymol. 614, 187-205.

Kumar, G.S., Choy, M.S., Koveal, D., Lorinsky, M.K., Lyons, S.P., Kettenbach, A.N., Page, R., Peti, W. (2018) Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase-1 holoenzyme, Science Advances. 4, eaau6044.

Kumar, G.S., Clarkson, M.W., Kunze, M.B.A., Granata, D., Wand, A. J., Lindorff-Larsen, K., Page, R., Peti, W. (2018) Dynamic activation and regulation of the mitogen-activated protein kinase p38, Proc. Natl. Acad. Sci. USA. 115 (18), 46550-4600.

Kumar, G.S., Gokhan, E., Munter, S., Bollen, M., Vagnarelli, P., Peti, W., Page, R. (2016)
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism, eLife, 5: e16539.

NMR SpectroscopyX-ray crystallographyProtein PhosphatasesProtein Kinases