Professor, Chemistry and Biochemistry-Med
Degrees and Appointments
- 1993, Biochemistry and Applied Mathematics, Magna cum laude, University of Arizona
- 1993-1999, PhD, Princeton University (Prof. C.E. Schutt)
- 2000-2004 Postdoctoral Researcher 4, The Scripps Research Institute (Prof. Ray Stevens)
- 2005 – 2016, Assistant Professor to Professor, Brown University
- 2017 - present, DONNA B. COSULICH FELLOW AND PROFESSOR University of Arizona
Awards and Honors
- 1992 Barry M. Goldwater Undergraduate Research Scholar
- 1994 – 1997 National Science Foundation Graduate Fellowship
- 1997 – 1998 Harold W. Dodds Honorific Graduate Fellowship
- 2000 – 2003 Ruth L Kirschstein National Research Service Award (NRSA), NIH
- 2005 Brown University Richard B. Salomon Faculty Research Award
- 2008 Hazeltine Citation Nominee (Brown University senior class teaching award)
- 2008 – 2011 American Cancer Society Research Scholar
- 2013 Eighteenth Annual Gehrenbeck Lecturer, Rhode Island College
- 7/2012 – present Editorial Board Member, Journal of Biological Chemistry
- 2010 – 2016 NSF-CAREER Award
- 1/2017 – present Associate Editor, Science Advances
- 2016-2018 NSLS II scientific proposal, standing reviewer
- 2016-2021 NIH – MSFB, standing study section member
How we sense and react to our environment is communicated in the cell by vast networks of highly dynamic, interacting proteins. These interactions are regulated in both space and time, and it is this tight regulation that allows signals from outside of the cell to be rapidly and precisely transmitted to the nucleus leading to the appropriate, and healthy, cellular response. My research integrates structural biology, biophysics and biochemistry in order to understand how these signals in both prokaryotes and eukaryotes are communicated in the cell at atomic resolution. During the last years, my group has focused on two problems: (1) how do toxin:antitoxin (TA) systems in bacteria lead to bacterial persistence and antibiotic resistance and (2) how are the activities of ser/thr phosphatases in the eukaryotic cell regulated. Our studies have made a transformative impacts in both fields. In microbiology and persistence, we: (1) discovered an entirely novel TA system (Type V; published in Nature Chemical Biology) and showed that a second TA system, MqsRA, defines a novel Type II subtype. In the second, a tour de force of crystallographic and functional studies led to the discovery of an entirely novel mechanism of substrate selection in ser/thr phosphatases: namely, that many PSP targeting and inhibitor proteins function to select substrates through a mechanism of steric inhibition. Furthermore, it also revealed the molecular basis by which the blockbuster immunosuppressants FK506 and cyclosporin A work—they bind and block one of the key calcineurin substrate binding grooves, demonstrating, for the first time, how these ubiquitous PSPs can be exploited for the development of highly specific drugs.SELECTED PUBLICATIONS:
Kumar, G.S., Ezgi, G., De Munter, S., Bollen, M., Vagnarelli, P., Peti, W. & Page, R. (2016) Molecular Assembly of the Ki-67:PP1 and RepoMan:PP1 Mitotic Phosphatases: Regulators of Chromatin Organization and Structure, Elife, 5:e16539.
Wang, X., Bajaj, R., Bollen, M., Peti, W. & Page, R. (2016) Expanding the PP2A Interactome by Defining a B56-specific SLiM, Structure, 24(12):2174-2181.
Sheftic, R.S., Page, R. & Peti, W. (2016) Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM, Nature Sci. Reports, 6:38920.
Page, R., Peti, W. (2016) Toxin:antitoxins systems in bacterial growth arrest and persistence. Nature Chem Biol, 12: 208-214.
Choy, M.S., Yusoff, P., Lee, I.C., Newton, J.C., Goh, C.W., Page, R., Shenolikar, S. & Peti, W. (2015) Structural and functional analysis of the GADD34:PP1 eIF2α phosphatase, Cell Reports, 11, 1885-1891
Choy, M.S., Hieke, M., Kumar, G.S., Lewis, G.R. Gonzalez-DeWhitt, K.R., Kessler, R.P., Stein, B.J., Hessenberger, M., Nairn, A.C., Peti, W. & Page, R. (2014) Understanding Retinoblastoma Protein activation by PNUTS leads to the identification of the Protein Phosphatase 1 Regulatory Code, Proc Natl Acad Sci U S A, 111(11), 4097-4102.
Grigoriu, S., Bond, R., Cossio, P., Chen, J.A., Ly, N., Hummer, Page, R., Cyert, M.S. & Peti, W. (2013) The molecular mechanism of substrate engagement and immunosuppressant inhibition of Calcineurin. PLoS Biology, 11(2), e1001492
Wang, X., Lord, D.M., Cheng, H.-Y., Osbourn, D.O., Hong, S.H., Sanchez-Torres, V., Quiroga, C., Herrmann, T., Peti, W., Benedik, M.J., Page, R. & Wood, T.K. (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS, Nat Chem Biol, 8, 855-861.
Wang, W., Kim, Y., Ma, Q., Hong, S.H., Brown, B.L., Benedik, M.J., Peti, W., Page, R. & Wood, T.K. (2011) Antitoxin MqsA Helps Mediate the Bacterial General Stress Response, Nat Chem Biol, 7(6), 359-366.X-ray crystallography NMR Spectroscopy Cell Signaling Cancer Antibiotic Resistance Protein Phosphatases Protein Kinases Toxin antitoxin systems