Njardarson Group
57

"Mild Stereoselective Formation of Tri- and Tetrasubstituted Olefins by Regioselective Ring Opening of 1,1-Disubstituted Vinyl Oxiranes with Dialkyl Dithiophosphates" Guo, B.; Vitaku, E.; Njardarson, J. T. Tetrahedron Lett. 2014, 55, ASAP.

56

"A Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction" Smith, D. T.; Njardarson, J. T. Angew. Chem. Int. Ed. 2014, 53, 4278.

55

"Evolution of an Oxidative Dearomatization Enabled Total Synthesis of Vinigrol" Yang, Q.; Draghici, C.; Njardarson, J. T.; Li, F.; Smith, B. R.; Das, P. Org. Biomol. Chem. 2014, 12, 330.                                        (Selected as an OBC Hot article)

54

"Base Mediated Deprotection Strategies for Trifluoroethyl (TFE) Ethers, a New Alcohol Protecting Group" Yang, Q.; Njardarson, J. T. Tetrahedron Lett. 2013, 54, 7080.

53

"Data-mining for Sulfur and Fluorine:  An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery" Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. J. Med. Chem. 2014, 57, 2832.

52

“Z-Selective Ring Opening of Vinyl Oxetanes with Dialkyl Dithiophosphate Nucleophiles” Guo, B.; Njardarson, J. T. Chem. Commun. 2013, 49, 10802.

51

“Ring Expansions of Vinyl- Oxiranes, Thiiranes and Aziridines: Synthetic Approaches, Challenges and Catalytic Success Stories” Ilardi, E. A.; Njardarson, J. T.  J. Org. Chem. 2013, 78, 9533.

50

"An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents that Chronicle Our Medicinal History" Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. J. Chem. Ed. 2013, 90, 1403.

49

"Total Synthesis of Vinigrol" Yang, Q.; Njardarson, J. T.; Draghici, C.; Li, F. Angew. Chem. Int. Ed. 2013, 52, 8648.     (Featured April 7th 2014 By Professor Taber on Organic Chemistry Portal)          Vinigrol featured in the October 2013 issue of Synform

48

"Catalytic Ring Expansion Adventures" Njardarson, J. T. Synlett, 2013, 787 (Invited Account)

47

"Recent Advances in the Metal-Catalyzed Ring Expansions of Three- and Four-Membered Rings" Mack, D. J.; Njardarson, J. T. ACS Catal. 2013, 3, 272.

46

"Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process" Mustard, T. J. L.; Mack, D. J.; Njardarson, J. T.; Cheong, Paul. H.-Y. J. Am. Chem. Soc. 2013, 135, 1471.

45

"Syntheses and Structural Confirmations of Members of a Heterocycle-Containing Family of Labdane Diterpenoids" Mack, D. J.; Njardarson, J. T. Angew. Chem. Int. Ed. 2013, 52, 1543.

44

"New Mechanistic Insights into the Copper Catalyzed Ring Expansion of Vinyl Aziridines:  Evidence in Support of a Copper(I) Mediated Pathway" Mack, D. J.; Njardarson, J. T. Chem. Sci. 2012, 3, 3321.

43

"Reactions at your fingertips" Njardarson, J. T. Nature Chem. 2012, 4, 590.

42

"Distinct Biological Effects of Golgicide A Derivatives on Larval and Adult Mosquitos" Mack, D. J.; Isoe, J.; Miesfeld, R. L.; Njardarson, J. T. Bioorg. Med. Chem. Lett. 2012, 22, 5177.

41

"Synthesis of Allylic and Homoallylic Alcohols from Unsaturated Cyclic Ethers Using a Mild and Selective C-O Reduction Approach" Mack, D. J.; Guo, B.; Njardarson J. T. Chem. Commun. 2012, 48, 7844.

40

"Catalytic Ring Expansion of VInyl Oxetanes:  Asymmetric Synthesis of Dihydropyrans Using Chiral Counterion Catalysis" Guo, B.; Schwarzwalder, G.; Njardarson, J. T. Angew. Chem. Int. Ed. 2012, 51, 5675.

39

"Chemistry By Design - A Web Based Educational Flashcard for Exploring Synthetic Organic Chemistry" Draghici, C.; Njardarson, J. T. J. Chem. Ed. 2012, 89, 1080.

38

"Pharmaceutical Structure Montages as Catalysts for Design and Discovery" Njardarson, J. T. Future Med. Chem. 2012, 4, 951.

37

"Efficient Synthesis of Thiopyrans Using Sulfur-Enabled Anionic Cascade" Li, F.; Calabrese, D.; Brichacek, M.; Lin, I.; Njardarson, J. T. Angew. Chem. Int. Ed. 2012, 51, 1938.

36

"Intermolecular Oxonium Ylide Mediated Synthesis of Medium-Sized Ocacycles" Mack, D. J.; Batory, L. A.; Njardarson, J. T. Org. Lett. 2012, 14, 378.

35

"Emergence of Potent Inhibitors of Metastasis in Lung Cancer vis Syntheses Based on Migrastatin" Lecomte, N.; Njardarson, J. T.; Nagorny, P.; Yang, G.; Downey, R.; Ouerfelli, O.; Moore, M. A. S.; Danishefsky, S. J. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 15074.

33

“Stereospecific Ring Expansion of Chiral Vinyl Aziridines” Brichacek, M.; Navarro Villalobos, M.; Plichta, A.; Njardarson J. T. Org. Lett. 2011, 13, 1110.

34

Synthetic Efforts Toward [3.3.1] Bridged Bicyclic Phloroglucinol Natural Products” Njardarson, J. T. Tetrahedron 2011, 67, 7631 (Invited Report).

32

“An Efficient Oxidative Dearomatization-Radical Cyclization Approach to Symmetrically Substituted Bicyclic Guttiferone Natural Products” McGrath, N. A.; Binner, J. R.; Markopoulos, G.; Brichacek, M.; Njardarson J. T. Chem. Commun. 2011, 47, 209.

31

“The Strategic Marriage of Method and Motif. Total Synthesis of Varitriol” Brichacek, M.; Batory, L. A.; McGrath, N. A.; Njardarson J. T. Tetrahedron 2010, 66, 4832.

30

“A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives” McGrath, N. A.; Brichacek, M.; Njardarson J. T. J. Chem. Ed. 2010, 87, 1348.

29

“A Stereoselective Ring Expansion of Vinyl Oxiranes. Mechanistic Insights and Natural Product Total Synthesis” Brichacek, M.; Batory, L. A.; Njardarson, J. T. Angew. Chem. Int. Ed. 2010, 49, 1648.

28

“A Concise Ring Expansion Route to the Compact Core of Platensimycin” McGrath, N. A.; Bartlett, E. S.; Sittihan, S.; Njardarson, J. T. Angew. Chem., Int. Ed. 2009, 48, 8543.

27

“Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton” Morton, J. G. M.; Dragichi, C.; Kwon, L. D.; Njardarson, J. T. Org. Lett. 2009, 11, 4492.

26

“Creative Approaches Towards the Synthesis of 2,5-Dihydro- Furans, Thiophenes and Pyrroles. One Method Does Not Fit All!” Brichacek, M.; Njardarson, J. T. Org. Biomol. 2009, 7, 1761.

25

“Efforts Towards the Total Synthesis of Vinigrol” Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. Synlett 2009, 23.

24

“An Adler-Becker Oxidation Approach to Vinigrol” Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. Tetrahedron Lett. 2009, 50, 1684.

23

“An Efficient Substrate Controlled Synthesis of Hypoestoxide, a Member of a Unique Family of Diterpenoid Natural Products with an Inside-Out [9.3.1]Bicyclic Core” McGrath, N.; Lee, C. A.; Araki, H.; Brichacek, M.; Njardarson, J. T. Angew. Chem. Int. Ed. 2008, 47, 9450.

22

“Lewis Acid Catalyzed [1,3]-Sigmatropic Rearrangement of Vinyl Aziridines” Brichacek, M.; Njardarson, J. T.; Lee-D.-L. Org. Lett. 2008, 10, 5023.

21

“PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice” McDewitt, M. R.; Chattopadhyay, D.; Jaggi, J. S.; Finn, R. D.; Zanzonico, P. B.; Villa, C.; Rey, D.; Mendenhall, J.; Batt, C. A.; Njardarson, J. T.; Scheinberg, D. A. PLoS One 2007, 2.

20

“Tumor Targeting with Antibody-Functionalized Radiolabled Carbon Nanotubes” McDewitt, M. R.; Chattopadhyay, D.; Kappel, B. J.; Jaggi, J. S.; Schiffman, S. R.; Antczak, C.; Njardarson, J. T.; Brentjens, R.; Scheinberg, D. A. J. Nuc. Med. 2007, 48, 1180.

19

“Highly Selective Copper-Catalyzed Ring Expansion of Vinyl Thiiranes: Application to Synthesis of Biotin and the Heterocyclic Core of Plavix®” Rogers, E.; Araki, H.; Batory, L. A.; McInnis, C. E.; Njardarson, J. T. J. Am. Chem. Soc. 2007, 129, 2768.

18

“Copper Catalyzed Rearrangement of Vinyl Oxiranes” Batory, L. A.; McInnis, C. E.; Njardarson, J. T. J. Am. Chem. Soc. 2006, 128, 16054.

Jon's undergraduate, graduate and post-doctoral publications

Independent Patents

6

 “Single Wall Carbon Nanotube Constructs For Targeting Tumors” Scheinberg, D.; McDewitt, M.; Antczak, C.; Chattopahyay, D.; May, R.; Njardarson, J.; Phillips M. R.; PCT Int. Appl., (2007), WO 2007016466.

5

 “Process For the Preparation of 2,5-Dihydrofuran Derivatives” Njardarson, J. T.; Batory, L. A.; Bricachek, M.; Bauer, R. A.; Rogers, E. PCT Int. Appl., (2007), WO 2007108999.

Patents From Post-Doctoral Work

4

 “Preparation of Migrastatin and its Analogs for use in Pharmaceutical Compositions for the Treatment of Cancer” Danishefsky, S. J.; Gaul, C.; Njardarson, J. T., Moore, M. A. S.; Wu, K.; Dorn, D. C.; Mandal, M.; PCT Int. Appl., (2006), WO 2006001967.

3

“Preparation of Migrastatin Analogs and their Biological Activity” Huang, X.-Y.; Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl. (2004), WO 2004087672.

2

“Preparation of Migrastatin Analogs and their Biological Activity” Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl., (2004), WO 2004087673.

1

“Synthesis of Epothilones for Therapeutic use as Anticancer Agents” Danishefsky, S. J.; Biswas, K.; Chappell, M. D.; Lin, H.; Njardarson, J. T.; Lee, C.; Rivkin, A.; Chou, T.-C. PCT Int. Appl. (2003), WO 2003022844.