We determine structures of complex bioactive natural products in collaboration with many groups around the world, mainly by NMR methods. Currently several anticancer agents and an antiviral agent are under study. In the synthesis area, we recently completed the first synthesis of an anticancer agent produced by soil bacteria from the Santa Catalina Mountains.
A.A. Bodour, C. Guerrero-Barajas, B.V. Jiorle, M.E. Malcomson, A.K. Paull, A. Somogyi, L.N. Trinh, R.B. Bates, and R.M. Maier, Appl. Environ. Microbiology, 70, 114 (2004). (Structure and Characterization of Flavolipids, a Novel Group of Biosurfactants Produced by Flavobacterium sp. Strain MTN11).
M.A. Ali, R.B. Bates,Z.D. Crane, C.W. Dicus, M.R. Gramme, E. Hamel, J. Marcischak, D.S. Martinez, K.J. McLure, P. Nakkiew, G.R. Pettit, C.C. Stessman, B.A. Sufi, and G.V. Yarick, Bioorg. Med. Chem., 13, 4138 (2005). (Dolastatin 11 conformations, analogues and pharmacophore).
S.D. Jolad, R.C. Lantz, G.J. Chen, R.B. Bates, B.N. Timmermann, Phytochem., 66, 1614 (2005). (Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production).